The Philadelphia Chromosome

The Philadelphia Chromosome

The Philadelphia Chromosome: A Mutant Gene and the Quest to Cure Cancer at the Genetic Level by Jessica Wapner
2013 | EPUB | 1.98MB

Philadelphia, 1959: A scientist scrutinizing a single human cell under a microscope detects a missing piece of DNA. That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research—the Philadelphia chromosome. This book charts not only that landmark discovery, but also—for the first time, all in one place—the full sequence of scientific and medical discoveries that brought about the first-ever successful treatment of a lethal cancer at the genetic level.

The significance of this mutant chromosome would take more than three decades to unravel; in 1990, it was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. This dramatic discovery launched a race involving doctors and researchers around the world, who recognized that in principle it might be possible to target CML at its genetic source.

Science journalist Jessica Wapner brings extensive original reporting to this book, including interviews with more than thirty-five people with a direct role in this story. Wapner reconstructs more than forty years of crucial breakthroughs, clearly explains the science behind them, and pays tribute to the dozens of researchers, doctors, and patients whose curiosity and determination restored the promise of a future to the more than 70,000 people worldwide who are diagnosed with CML each year. Chief among them is researcher and oncologist Dr. Brian Druker, whose dedication to his patients fueled his quest to do everything within his power to save them.

The Philadelphia Chromosome helps us to fully understand and appreciate just how pathbreaking, hard-won, and consequential are the achievements it recounts—and to understand the principles behind much of today’s most important cancer research, as doctors and scientists race to uncover and treat the genetic roots of a wide range of cancers.

The Liar in Your Life: The Way to Truthful Relationships

The Liar in Your Life: The Way to Truthful Relationships

The Liar in Your Life: The Way to Truthful Relationships by Robert Feldman
2010 | EPUB | 268.43KB

In The Liar in Your Life, psychology professor Robert Feldman, one of the world's leading authorities on deception, draws on his immense body of knowledge to give fresh insights into how and why we lie, how our culture has become increasingly tolerant of deception, the cost it exacts on us, and what to do about it. His work is at once surprising and sobering, full of corrections for common myths and explanations of pervasive oversimplifications.

Feldman examines marital infidelity, little white lies, career-driven resumé lies, and how we teach children to lie. Along the way, he reveals-despite our beliefs to the contrary- how it is nearly impossible to spot a liar (studies have shown no relationship between nervousness, lack of eye contact, or a trembling voice, and acts of deception). He also provides startling evidence of just how integral lying is to our culture; indeed, his research shows that two people, meeting for the first time, will lie to each other an average of three times in the first ten minutes of a conversation.

Feldman uses this discussion of deception to explore ways we can cope with infidelity, betrayal, and mistrust, in our friends and family. He also describes the lies we tell ourselves: Sometimes, the liar in your life is the person you see in the mirror. With incisive clarity and wry wit, Feldman has written a truthful book for anyone who whose life has been touched by deception.

The Third Reich of dreams: The nightmares of a nation

The Third Reich of dreams: The nightmares of a nation

The Third Reich of dreams: The nightmares of a nation, 1933-1939 by Charlotte Beradt
1968 | PDF | 7.77MB

These are the records of a psychoanalyst who kept a diary of patient dreams in Germany during the rise of the Third Reich. The book traces the ways in which the rising tide of Fascism infected the unconscious lives of ordinary Germans, skewing their dreams towards increasingly brutal and nightmarish reflections of the pathology of Nazism. A profound and disturbing book.

During the 1930's, Nazi Germany's rise to totalitarian power was well under way. Warning signs of the terror to come was being felt by increasing numbers of people. Among them was a young woman of great courage & insight. Charlotte Beradt recorded & collected people's dreams about the Nazi government's domination of their lives; dreams telling of the painful political realities of the emerging Nazi State. In his essay at the conclusion of the volume, published in 1966, Bruno Bettelheim remarked it was a shocking experience reading this book of dreams & seeing how effectively the Nazis murdered sleep, "forcing its enemies to dream dreams that showed that resistance was impossible & safety lay only in compliance.

Vitamin O: Why Orgasms are Vital to a Woman's Health

Vitamin O: Why Orgasms are Vital to a Woman's Health

Vitamin O: Why Orgasms are Vital to a Woman's Health and Happiness, and How to Have Them Every Time by Natasha Janina Valdez
2011 | EPUB | 800.19KB

Orgasms are the magic bullet—here’s how to enjoy them as often as possible.

They’re free, fun, and with this book, easy to achieve. And just look what a woman stands to gain from her orgasmic life:

  • Oxytocin—nature’s Ecstasy—in her bloodstream
  • Relaxation—less stress and tension
  • Falling asleep and staying asleep better
  • More supple skin (really!)
  • Lower risk of heart disease
  • Immunity boost
  • Reduced hunger and cravings for junk food

Far too many women aren’t enjoying the benefits of this delicious activity, and Dr. Natasha wants to change that. In Vitamin O, she explores manual techniques, oral methods, and crazy-fun sex positions that maximize a woman’s pleasure. She covers the basics in orgasmic foreplay, orgasmic positions, exercises to improve orgasms, orgasm-enhancing yoga, breathing techniques, and more. Here is the 411 on more advanced climaxing—multiples and simultaneous orgasms. And she breaks out lots of quick fixes for getting a daily dose without any fuss. By the time she’s through, having orgasms will become as natural and pleasantly habitual as drinking a morning coffee (which you’ll be drinking less and less of, as you’ll have increased energy from better sleep.)

Vitamin O’s benefits are layered and far-reaching, without any worry of toxicity or build-up—because Vitamin O is all about release. Regular doses will benefit every reader for life. 20 black-and-white illustrations

69 Things to Do With a Dead Princess

69 Things to Do With a Dead Princess

69 Things to Do With a Dead Princess by Stewart Home
2012 | EPUB | 725.05KB

This is where the novel has a nervous breakdown. Anna Noon is a twenty-year-old student with a taste for perverse sex involving an enigmatic older man and a ventriloquist's dummy. Anna lives in Aberdeen and her sex life revolves around the ancient stone circles in the region.The sublime grandeur of the stones provides a backdrop against which Anna is able to act out her provocative psychodramas.

The Revolution of Everyday Life

The Revolution of Everyday Life

The Revolution of Everyday Life by Raoul Vaneigem
2012 | EPUB | 1.44MB

One of the most important exponents of Situationist ideas, this treatise presents an impassioned critique of modern capitalism and serves as a cornerstone of modern radical thought. Originally published in early 1968, the book both kindled and colored the May 1968 upheavals in France that captured the attention of the world.

In the political climate of today, Raoul Vaneigem’s important work of radical anticapitalist thought has struck a new chord with the worldwide Occupy Movement. Naming and defining the alienating features of everyday life in consumer society—survival rather than living in full, the call to sacrifice, the cultivation of false needs, the dictatorship of the commodity, subjection to social roles, and the replacement of God by the economy—the book argues that the countervailing impulses that exist deep within this alienation, such as creativity, spontaneity, and poetry, present an authentic alternative to nihilistic consumerism.

This carefully edited new translation marks the first North American publication of this important work and includes a new preface by the author and a translator’s note.

"Anyone who talks about revolution and class struggle without referring explicitly to everyday life—without grasping what is subversive about love and positive in the refusal of constraints—has a corpse in his mouth."

Mastering the Core Teachings of the Buddha

Mastering the Core Teachings of the Buddha

Mastering the Core Teachings of the Buddha: An Unusually Hardcore Dharma Book by Daniel M Ingram
2008 | MOBI | 584.01KB

Author posits that enlightenment is an attainable goal.
Argues that meditation is a method for examining reality.

The very idea that the teachings of meditation can be mastered will arouse controversy within Buddhist circles. Even so, Ingram insists that enlightenment is an attainable goal, once our fanciful notions of it are stripped away, and we have learned to use meditation as a method for examining reality rather than an opportunity to wallow in “self-absorbed mindnoise”.

Ingram sets out concisely the difference between concentration-based and insight (vipassana) meditation; he provides example practices; and most importantly he presents detailed maps of the states of mind we are likely to encounter, and the stages we must negotiate as we move through clearly-defined cycles of insight. It’s easy to feel overawed, at first, by Ingram’s assurance and ease in the higher levels of consciousness, but consistently he writes as a down-to-earth and compassionate guide—to the practitioner willing to commit themselves this is a glittering gift of a book.

On the Shores of the Mediterranean

On the Shores of the Mediterranean

On the Shores of the Mediterranean by Eric Newby
2013 | EPUB | 2.71MB

With his trademark charm and sharp wit, Newby leaves no stone unturned in his quest for wonderfully detailed and quirky knowledge to share with his reader. Insightful, hilarious and sheer fun, this is an adventure not to be missed, by Britain's best-loved travel guide, and father of the genre. 'Why don't you start in Naples and go clockwise round the Mediterranean instead of dashing off in all directions like a lunatic?' Fortunately, Eric Newby followed his wife Wanda's advice, and so begins the wonderfully madcap adventure, 'On the Shores of the Mediterranean'.

Beginning during the Newbys' wine harvest in Tuscany, the adventurous but disaster-prone pair follow a path using every form of transportation conceivable (public bus, taxi, foot, bike, boat), from Naples to Venice, along the Adriatic to Greece, Turkey, Jerusalem and North Africa, from sipping wildly extravagant cocktails in San Marco to being cordially invited to Libya by Colonel Gaddafi.

A Small Place in Italy

A Small Place in Italy

A Small Place in Italy by Eric Newby
2013 | EPUB | 736.66KB

This book is a lush and beautiful memoir of a very special house and a superb recreation of a bygone era. In 1967, veteran travel writer Eric Newby and his heroic wife Wanda fulfiled their dream of a return to life in the Italian hills where they first met during World War II. But this fulfilment would not come easy. The dream materialised in the form of I Castagni ('The Chestnuts', a small, decrepit farmhouse with no roof, an abandoned septic tank and its own indigenous wildlife reluctant to give up their home. But in the foothills of the Apuan Alps on the border of Liguria and Northern Tuscany, this ramshackle house would soon become a hub of love, friendship and activity.

Whether recounting dangerous expeditions through Afghanistan or everyday life in a country house, Newby's talent shines through as one of the foremost writers of the comic travel genre. Full of Newby's sharp wit and good humour, 'A Small Place' in Italy returns, twenty years later, to the life of Newby's much-cherished classic, Love and War in the Apennines. It lovingly recounts the quickly disappearing lifestyle of the idiosyncratic locals, and the enduring friendships they forge, whether sharing in growing their first wine harvest as novices or frying poisonous mushrooms for a feast.

Round Ireland in Low Gear

Round Ireland in Low Gear

Round Ireland in Low Gear by Eric Newby
2011 | EPUB | 2.29MB

'You've had some pretty crazy ideas in your life, Newby, but this is the craziest.' Grandmother Wanda Newby was exasperated after continuous rain, snow, and gales that knocked from her bike. Twice. To avoid other tourists, Eric Newby had decided that the depths of winter would be the very best time to explore Ireland by mountain bike. More astonishing still, he managed to persuade Wanda, his long-suffering wife and life-long co-traveller, to accompany him - mainly, she admitted, to 'keep him out of trouble'.

Lashed by winter storms, fuelled by Guinness and warmed by thermal underwear, their panniers laden with antique books on Ireland, the elderly adventurers cycle the highways and byways, encountering hospitable locals, swaying saints and ferocious dogs. From the shores of Donegal to the holy mountains, Newby guides the reader on a tale of mishap and magic, all in his own peculiar style of humour and charm, relishing his never-ending curiosity of the world and his insatiable quest for adventure.

Absolute Monarchs: A History of the Papacy

Absolute Monarchs: A History of the Papacy

Absolute Monarchs: A History of the Papacy by John Julius Norwich
2011 | EPUB | 9.64MB

With the papacy embattled in recent years, it is essential to have the perspective of one of the world’s most accomplished historians. In Absolute Monarchs, John Julius Norwich captures nearly two thousand years of inspiration and devotion, intrigue and scandal. The men (and maybe one woman) who have held this position of infallible power over millions have ranged from heroes to rogues, admirably wise to utterly decadent. Norwich, who knew two popes and had private audiences with two others, recounts in riveting detail the histories of the most significant popes and what they meant politically, culturally, and socially to Rome and to the world.

Norwich presents such brave popes as Innocent I, who in the fifth century successfully negotiated with Alaric the Goth, an invader civil authorities could not defeat, and Leo I, who two decades later tamed (and perhaps paid off) Attila the Hun. Here, too, are the scandalous figures: Pope Joan, the mythic woman said (without any substantiation) to have been elected in 855, and the infamous “pornocracy,” the five libertines who were descendants or lovers of Marozia, debauched daughter of one of Rome’s most powerful families.

Absolute Monarchs brilliantly portrays reformers such as Pope Paul III, “the greatest pontiff of the sixteenth century,” who reinterpreted the Church’s teaching and discipline, and John XXIII, who in five short years starting in 1958 “opened up the church to the twentieth century,” instituting reforms that led to Vatican II. Norwich brings the story to the present day with Benedict XVI, who is coping with a global priest sex scandal.

Epic and compelling, Absolute Monarchs is the astonishing story of some of history’s most revered and reviled figures, men who still cast light and shadows on the Vatican and the world today.

Paradise of Cities: Venice in the 19th Century

Paradise of Cities: Venice in the 19th Century

Paradise of Cities: Venice in the 19th Century by John Julius Norwich
2007 | EPUB | 5.5MB

John Julius Norwich's A History of Venice has been dubbed "indispensable" by none other than Jan Morris. Now, in his second book on the city once known as La Serenissima, Norwich advances the story in this elegant chronicle of a hundred years of Venice's highs and lows, from its ignominious capture by Napoleon in 1797 to the dawn of the 20th century.

An obligatory stop on the Grand Tour for any cultured Englishman (and, later, Americans), Venice limped into the 19th century--first under the yoke of France, then as an outpost of the Austrian Hapsburgs, stripped of riches yet indelibly the most ravishing city in Italy. Even when subsumed into a unified Italy in 1866, it remained a magnet for aesthetes of all stripes--subject or setting of books by Ruskin and James, a muse to poets and musicians, in its way the most gracious courtesan of all European cities. By refracting images of Venice through the visits of such extravagant (and sometimes debauched) artists as Lord Byron, Richard Wagner, and the inimitable Baron Corvo, Norwich conjures visions of paradise on a lagoon, as enduring as brick and as elusive as the tides.

The Middle Sea: A History of the Mediterranean

The Middle Sea: A History of the Mediterranean

The Middle Sea: A History of the Mediterranean by John Julius Norwich
2007 | EPUB | 9.13MB

This lively and dramatic book brings roaring to life the grand sweep of 5,000 years of history in the cradle of civilization.

A wonderfully illustrated account of the civilizations that rose and fell on the lands bordering the Mediterranean, The Middle Sea represents the culmination of a great historian's unparalleled art and scholarship. John Julius Norwich provides brilliant portraits of the Phoenicians, the Egyptians, the Greeks, the Romans, the Byzantines, the Arabs, the French, the Venetians, the Popes, and the pirates of the Gulf. Above all, he deftly traces the intermingling of ancient conflicts and modern sensibilities that shapes life today on the shores of the Middle Sea.

The Duchess of Windsor: A Memoir

The Duchess of Windsor: A Memoir

The Duchess of Windsor: A Memoir by Diana Mitford (Lady Mosley)
2011 | EPUB | 14.92MB

A consummate writer and intimate of the Duke and Duchess of Windsor, Diana Mosley was a frequent guest at their parties in Paris or at 'the Moulin' in Orsay, where they were neighbours. Written in her inimitable style - archly intelligent, witty and perceptive - Diana Mosley paints a remarkable portrait of her friend that is both extremely life-like and realistic with regards to her flaws. What was it that utterly captivated the heir to the throne and made him renounce it so that he might never be parted from her? It is this question which Diana Mosley seeks to answer and which she is perhaps better qualified to answer than anyone else, given her love of her husband Sir Oswald Mosley, Leader of the British Fascists.

The Ultimate History of Video Games

The Ultimate History of Video Games

The Ultimate History of Video Games by Steven Kent
2010 | EPUB | 4.93MB

The Ultimate History of Video Games reveals everything you ever wanted to know and more about the unforgettable games that changed the world, the visionaries who made them, and the fanatics who played them. From the arcade to television and from the PC to the handheld device, video games have entraced kids at heart for nearly 30 years. And author and gaming historian Steven L. Kent has been there to record the craze from the very beginning.

This engrossing book tells the incredible tale of how this backroom novelty transformed into a cultural phenomenon. Through meticulous research and personal interviews with hundreds of industry luminaries, you'll read firsthand accounts of how yesterday's games like Space Invaders, Centipede, and Pac-Man helped create an arcade culture that defined a generation, and how today's empires like Sony, Nintendo, and Electronic Arts have galvanized a multibillion-dollar industry and a new generation of games.

The I Hate to Cook Book: The 50th Anniversary Edition

The I Hate to Cook Book: The 50th Anniversary Edition

The I Hate to Cook Book: The 50th Anniversary Edition of The American Classic by Peg Bracken, Johanna Bracken
2010 | EPUB | 1.8MB
"There are two kinds of people in this world: the ones who don't cook out of and have NEVER cooked out of THE I HATE TO COOK BOOK, and the other kind...The I HATE TO COOK people consist mainly of those who find other things more interesting and less fattening, and so they do it as seldom as possible. Today there is an Annual Culinary Olympics, with hundreds of cooks from many countries ardently competing. But we who hate to cook have had our own Olympics for years, seeing who can get out of the kitchen the fastest and stay out the longest." - Peg Bracken

Philosopher's Chowder. Skinny Meatloaf. Fat Man's Shrimp. Immediate Fudge Cake. These are just a few of the beloved recipes from Peg Bracken's classic I HATE TO COOK BOOK. Written in a time when women were expected to have full, delicious meals on the table for their families every night, Peg Bracken offered women who didn't revel in this obligation an alternative: quick, simple meals that took minimal effort but would still satisfy.

50 years later, times have certainly changed - but the appeal of THE I HATE TO COOK BOOK hasn't.

This book is for everyone, men and women alike, who wants to get from cooking hour to cocktail hour in as little time as possible.

Something Wholesale: My Life and Times in the Rag Trade

Something Wholesale: My Life and Times in the Rag Trade

Something Wholesale: My Life and Times in the Rag Trade by Eric Newby
2010 | EPUB | 872.41KB

Veteran travel writer Eric Newby has a massive following and is cherished as the forefather of the modern comic travel book. However, less known are his adventures during the years he spent as an apprentice and commercial buyer in the improbable trade of women's fashion. From his repatriation as a prisoner of war in 1945 to his writing of the bestselling A Short Walk in the Hindu Kush in 1956, Eric Newby's years as a commercial traveller in the world of haute couture were as full of adventure and oddity as any during his time as travel editor for the Observer.

Something Wholesale is Newby's hilarious and wonderfully chaotic tale of the disorder that was his life as an apprentice to the family garment firm of Lane and Newby, including hilariously recounted escapades with sudden-onset wool allergies, waist-deep predicaments in tissue paper and the soul-destroying task of matching buttons. In addition to the charming chaos of his work in the family business, it is also a warm and loving portrait of his father, a delightfully eccentric gentleman who managed to spend more energy avoiding and actively participating in disasters than he did in preserving his business. With its quick wit, self-deprecating charm and splendidly fascinating detail, this is vintage Newby - only with a garment bag in place of a well-worn suitcase.